Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study with acceptable restrictions

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
2007
Report date:
2007
Reference Type:
study report
Title:
Unnamed
Year:
2007
Report date:
2007

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Pentacarbonyliron
EC Number:
236-670-8
EC Name:
Pentacarbonyliron
Cas Number:
13463-40-6
Molecular formula:
C5FeO5
IUPAC Name:
pentacarbonyliron
Details on test material:
- Analytical purity: 99.95%
Radiolabelling:
no

Study design

Analytical monitoring:
yes
Details on sampling:
- Sampling intervals for the parent/transformation products: ca. 1-3h
- Sampling intervals/times for pH measurements: measurment at the beginning and end of experiment
- Other observation, if any (e.g.: precipitation, color change etc.):
pH4: little, brown precipitation was observed at the end of the experiment
pH10: markedly brown precipitation was observed at the end of the experiment
Details on test conditions:
TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: abiotic, volumes of measuring chambers: pH4) 195.8 cm3, pH 6.3) 200.8 cm3, pH 10) 191.4cm3
- Measures taken to avoid photolytic effects: darkened measuring chamber
- Measures to exclude oxygen: closed, pressure tight measuring chamber
- Details of traps for volatile, if any: no data
- If no traps were used, is the test system closed/open: closed
- Is there any indication of the test material adsorbing to the walls of the test apparatus?: no
TEST MEDIUM
- Volume used/treatment: 100 ml
- Kind and purity of water: HPLC gradient grade, CAS: 7732-18-5, Fisher Scientific
- Preparation of test medium: heterogenous mixture was achieved by slowly stirring (0.1g pentacarbonyliron / 100 g Water)
- Renewal of test solution: no
- Identity and concentration of co-solvent: no co-solvent
OTHER TEST CONDITIONS
- Adjustment of pH: yes, at the beginning of the experiment
- Dissolved oxygen: no data
Duration of testopen allclose all
Duration:
474.8 h
pH:
4
Temp.:
21.9
Initial conc. measured:
ca. 45 mg/L
Duration:
477.5 h
pH:
6.3
Temp.:
25
Initial conc. measured:
ca. 39 mg/L
Duration:
474.8 h
pH:
10
Temp.:
21.9
Initial conc. measured:
ca. 45 mg/L
Positive controls:
not specified
Negative controls:
not specified

Results and discussion

Transformation products:
yes
Dissipation DT50 of parent compoundopen allclose all
pH:
4
Temp.:
25 °C
DT50:
180 h
St. dev.:
20
Type:
(pseudo-)first order (= half-life)
pH:
6.3
Temp.:
25 °C
DT50:
160 h
St. dev.:
20
Type:
(pseudo-)first order (= half-life)
pH:
10
Temp.:
25 °C
DT50:
170 h
St. dev.:
20
Type:
(pseudo-)first order (= half-life)
Details on results:
TEST CONDITIONS
- pH, sterility, temperature, and other experimental conditions maintained throughout the study: No
- Anomalies or problems encountered: pH10: the pH dropped from originally 10 to pH 7.2 in the course of the experiment

Applicant's summary and conclusion