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Registration Dossier
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EC number: 236-670-8 | CAS number: 13463-40-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: early study report, basic information given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 958
- Report date:
- 1958
Materials and methods
- Principles of method if other than guideline:
- The approximative dose (ALD50) was determined according to the methods of Behrens (cited in J.H. Burn: Bthol. Standardization, 1937).
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Pentacarbonyliron
- EC Number:
- 236-670-8
- EC Name:
- Pentacarbonyliron
- Cas Number:
- 13463-40-6
- Molecular formula:
- C5FeO5
- IUPAC Name:
- pentacarbonyliron
- Details on test material:
- no further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: "normal"
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- The mean body weights of the rats was 135.8 g.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aqueous emulsion with 1% Traganth
- Doses:
- 2.0, 7.9, 15.9, 20.4, 25.1, 31.6, 40, 63, 316 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- approximate LD50
- Effect level:
- ca. 25 mg/kg bw
- Mortality:
- All high-dosed animals died after 48 hours. No deaths were observewd in the three low dose groups (for details see table below).
- Clinical signs:
- The animals showed no remarkable symptoms before application.
The toxic symptoms were unspecific. The animals were apathetic and atonic after the application, breathing was accelerated and frequently intermittent. - Body weight:
- no remarkable changes
- Gross pathology:
- The lethal contaminated animals died not acutely, but within 1 - 4 days. The surviving animals were killed after 14 days and necropsied. No pathological changes were observed macroscopically at the organs.
Any other information on results incl. tables
Mortality:
| Dose (mg/kg) | Mortality after | untreated control | ||
| 24 hours | 48 hours | 7 hours | ||
| 316 | 3/5 | 5/5 | 5/5 | |
| 63 (first dosage) | 3/5 | 5/5 | 5/5 | |
| 63 (second dosage) | 0/5 | 0/5 | 1/5 | |
| 40 (first dosage) | 0/5 | 1/5 | 2/5 | |
| 40 (second dosage) | 5/5 | 5/5 | 5/5 | 12/12 |
| 31.6 | 0/5 | 4/5 | 4/5 | 7/8 |
| 25.1 | 0/5 | 0/5 | 1/5 | 3/8 |
| 20.4 | 0/5 | 1/5 | 2/5 | 2/10 |
| 15.9 | 0/5 | 0/5 | 0/5 | |
| 7.9 | 0/5 | 0/5 | 0/5 | |
| 2.0 | 0/5 | 0/5 | 0/5 | |
Applicant's summary and conclusion
- Interpretation of results:
- highly toxic
- Remarks:
- Migrated information
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