Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Dermal:
A single semi-occlusive application of butyl benzotriazole, sodium salt to intact rabbit skin for four hours elicited severe persistent dermal irritation.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Necrotic lesions and reactions resembling a chemical burn were observed in aIl three animals. The necrotic lesions persisted throughout the study. Slight or moderate oedema was present in all three animals initially and very slight oedema persisted throughout the study. Scab formation was observed around the necrotic areas in all three animals on day 14.


Justification for selection of skin irritation / corrosion endpoint:
reliable study available

Effects on skin irritation/corrosion: corrosive

Justification for classification or non-classification

Severe persistent dermal irritation was abserved following a single semi-occlusive application of butyl benzotriazole, sodium salt to intact rabbit skin for four hours.

The results of this study established that Butyl benzotriazole, sodium salt has to be classified:

Corrosive with Risk Phase R 34: Causes burns according Directive 67/548 EEC (DSD);

Skin Corr. 1B with Hazardous statement H314: cause severe skin burns and eye damage, according regulation (EC) 1272/2008 (CLP)