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EC number: 469-910-7 | CAS number: 847842-48-2
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Explosiveness
Administrative data
Link to relevant study record(s)
Description of key information
A study (Tremain, 2007) conducted on the reference substance concluded that based on the chemical structure of the test material the result for the explosive properties has been predicted negative.
Additional study conducted on the reference substance:
(Gilmore, 2003) The analogue material has been shown to have a dust explosivity (Limiting Oxygen Concentration) of 11 % v/v.
Studies conducted on the conducted on the analogue substance Abacavir Hemisulphate
(Weaver, 1996) The analogue material could be considered to produce a weak explosion when subjected to explosion severity (20 Litre Sphere) testing.
(Gilmore, 2003) The analogue material has been shown to have a dust explosivity (Limiting Oxygen Concentration) of 10 % v/v
Studies conducted on the conducted on the analogue substance Abacavir Succinate
(Weaver, 1996) The analogue material could be considered to produce a weak explosion when subjected to explosion severity (20 Litre Sphere) testing.
(Bundy, 1996) The analogue material has been shown to be insensitive to explosion initiation by mechanical stimulation. Only minor decomposition was observed in the fallhammer test indicating that decomposition may be initiated by significant impact.
(Bundy, 1996) The analogue material has been shown to be insensitive to explosion initiation by mechanical stimulation. Only minor decomposition was observed in the friction test indicating that decomposition may be initiated by friction energies.
(Bundy, 1996) The analogue material has been shown to be insensitive to thermal shock and, therefore is not considered to possess thermoexplosive properties.
Key value for chemical safety assessment
- Explosiveness:
- non explosive
Additional information
An explosive properties study (Tremain, 2007)on the reference substance predicted using Method A14 of Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC) concluded that based on the chemical structure of the test material the result for the explosive properties has been predicted negative.
Additional study conducted on the reference substance:
(Gilmore, 2003) The analogue material has been shown to have a dust explosivity (Limiting Oxygen Concentration) of 11 % v/v.
Studies conducted on the conducted on the analogue substance Abacavir Hemisulphate
(Weaver, 1996) The analogue material could be considered to produce a weak explosion when subjected to explosion severity (20 Litre Sphere) testing.
(Gilmore, 2003) The analogue material has been shown to have a dust explosivity (Limiting Oxygen Concentration) of 10 % v/v
Studies conducted on the conducted on the analogue substance Abacavir Succinate
(Weaver, 1996) The analogue material could be considered to produce a weak explosion when subjected to explosion severity (20 Litre Sphere) testing.
(Bundy, 1996) The analogue material has been shown to be insensitive to explosion initiation by mechanical stimulation. Only minor decomposition was observed in the fallhammer test indicating that decomposition may be initiated by significant impact.
(Bundy, 1996) The analogue material has been shown to be insensitive to explosion initiation by mechanical stimulation. Only minor decomposition was observed in the friction test indicating that decomposition may be initiated by friction energies.
(Bundy, 1996) The analogue material has been shown to be insensitive to thermal shock and, therefore is not considered to possess thermoexplosive properties.
Although two of the studies (Weaver, 1996 - Abacavir Hemisulphate & Abacavir Succinate) concluded that the analogue substance should be considered explosive, the method is such that this conclusion would be reached with materials that would not normally be considered to be explosive. As such the study can be considered to be unreliable.
Based on this conclusion and the fact that the first study was conducted on the substance of interest, the study carried out by Tremain (2007) is considered to be the study of interest.
Abacavir Glutarate:
Tremain 2007:
The explosive properties were predicted using Method A14 of Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC).
Based on the chemical structure of the test material the result for the explosive properties has been predicted negative.
Gilmore 2003:
The test was performed using a 20 litre sphere apparatus and KSEP software manufactured by Adolf Kuhner AG. The SOP is based on ISO 6184 Part 1 (1985) Explosion Protection Systems, Part 1 : Method for determination of explosion indices of combustible dusts in air.
Dust explosivity: Limiting Oxygen Concentration: 11 % v/v
If nitrogen purging is considered as the preventive system, it must operate with an oxygen level below 11 %v/v.
Abacavir Hemisulphate:
Weaver 1996:The test was conducted using a 20 litre spherical pressure test chamber according to the test conditions specified in ISO 6184/1 - 1985.
The test material is considered to produce a weak explosion when subjected to explosion severity (20 Litre Sphere) testing.
Bundy 1996:
The result of > 60 J means that the the test material is not impact sensitive (according to the UN Transport of Dangerous Goods Recommendations and the EC Official Journal No L 383 A 14 protocols).
In conclusion, the material has been shown to be insensitive to explosion initiation by mechanical stimulation. Only minor decomposition was observed in the fallhammer test indicating that decomposition may be initiated by significant impact.
Bundy 1996:
The test material exhibited "decomposition" on all of the trials at 360 N.
Limiting Load > 360 N
This result of > 360 N means that the test material is insensitive to friction (according to the UN Transport of Dangerous Goods Recommendations and the EC Official Journal No L 383 A 14 protocols).
In conclusion, the test material has been shown to be insensitive to explosion initiation by mechanical stimulation. Only minor decomposition was observed in the friction test indicating that decomposition may be initiated by friction energies.
Gilmore 2003:
The test was performed using a 20 litre sphere apparatus and KSEP software manufactured by Adolf Kuhner AG. The SOP is based on ISO 6184 Part 1 (1985) Explosion Protection Systems, Part 1 : Method for determination of explosion indices of combustible dusts in air.
Dust explosivity: Limiting Oxygen Concentration: 10 % v/v
If nitrogen purging is considered as the preventive system, it must operate with an oxygen level below 10 %v/v.
Abacavir Succinate:
Weaver 1996:The test was conducted using a 20 litre spherical pressure test chamber according to the test conditions specified in ISO 6184/1 - 1985.
The test material is considered to produce a weak explosion when subjected to explosion severity (20 Litre Sphere) testing.
Bundy 1996:
The Koenen tube test showed the sample to be insensitive to thermal shock (according to the UN Transport of Dangerous Goods Recommendations, Test series 1 (and 2), and the Be Official Journal No L 383 A 14 protocols) and, therefore is not considered to possess thermoexplosive properties. However, the energy of decomposition was observed to be large.
Justification for classification or non-classification
The chemical structure of the reference substance has been assessed for explosive properties with a negative result predicted using Method A14 of Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC).
The analogue substance has been assessed for explosivity using a 20 litre spherical pressure test chamber according to the test conditions specified in ISO 6184/1 - 1985.
This study cannot be considered to be a reliable method for testing the explosivity of a test material.
Based on an assessment of the reliability of the methods used to assess explosivity the substance, Method A14 of Commission Directive 92/69/EEC is considered to be the preferred method and based on this the test material is not considered to be explosive.
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