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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

All studies were carried out on one of the analogue materials. The analogues are considered to be sufficiently similar to the substance of interest (please see attached data matrix and justification in Section 13 for additional details) for them to be used for the purposes of health and environment risk assessments.

Swarbrick 2004

A 96 hour acute toxicity to rainbow trout study was undertaken under static conditions using OECD Guideline 203. The analogue substance was tested at the following concentrations 7.5, 15, 30, 60 and 120 mg/L.

The substance was calculated to have an LC50 value after 96 hours of > 120 mg/L. The test item was determined to have a 96 hour NOEC value of 120 mg/L.

Jenkins 1997 A 48 -hour acute toxicity to Daphnia magna study was conducted in accordance with US FDA Environmental Assessment Technical Assistance Handbook (March 1987) - Document 4.08 and, where possible, Procedure 202 ofthe OECD Guidelines (1984). The 48-hour median effect concentration (EC50) for immobility, based on measured concentrations of volatile free 1592U89 was found to be 119 mg/L (with 95% confidence limits of 60.6 and 251 mg/L).

Swarbrick 2004

A study to assess the toxicity of the test material to the green alga Selenastrum capricornutum according to OECD guideline 201, Alga, Growth Inhibition test.

Based on areas under the growth curve the results obtained at 72 hours were:

No observed effect (P=0.05) concentration (NOEC) = 30 mg/L

Median effective concentration, biomass (EbC50) = 57.4 mg/L (95% confidence limits = 56.9 - 57.8 mg/L)

Jenkins 1997

A study was carried out to assess the effects of 1592U89 on sewage micro-organisms by measuring the rate of oxygen uptake of activated sludge at 20° ± 2°C, in its presence at a range of concentrations. The methods employed were designed to meet the requirements of EC Directive 87/302, 'Biodegradation Activated Sludge Respiration Inhibition test' and OECD test guideline 209, 'Activated Sludge, Respiration Inhibition test'.

The test material is considered to be of low toxicity to activated sludge.