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EC number: 219-941-5 | CAS number: 2579-20-6
In the examination of offspring, no changes attributed to the test substance were noted in the number of offspring, live birth index, sex ratio, viability index on Day 4, external features, clinical signs, body weights, or necropsy findings.
A combined repeated dose toxicity and reproductive toxicity screening study was conducted on the test substance 1,3-Bis(aminomethyl)cyclohexane (1,3-BAC). The study was performed according to OECD test guideline 422, and in compliance with GLP.
Male and female rats were dosed at levels 0 (vehicle control), 10, 60, and 300 mg/kg bw/day of 1,3-BAC as a solution in water; males were dosed for 42 days in total including the mating period, females were dosed from 14 days before mating until day 4 of lactation. The clinical and pathological effects on reproduction in both the parental generation and the offspring were recorded.
The test substance had no effects on the reproductive parameters of the parental animals, nor on the developmental parameters of the offspring. The no observed effect level of 1,3-Bis(aminomethyl)cyclohexane for reproductive / developmental toxicity was considered to be 300 mg/kg/day in parental animals and offspring.
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