Registration Dossier
Registration Dossier
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EC number: 906-151-7 | CAS number: -
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no information about strain used, exposure time : 1 hr, only one concentration
Data source
Reference
- Reference Type:
- publication
- Title:
- Bio fax data sheet: m-cresol
- Author:
- Industrial Bio-test Laboratory Inc.
- Year:
- 1 969
- Bibliographic source:
- Industrial Bio-test Laboratory Inc, Northbrook, Ill/USA, Data sheet no 3-5/69
Materials and methods
- Principles of method if other than guideline:
- Method: other: 6 rats exposed to 0.71 mg/l for 1 hr, room temperature, up to 14 d post exposure observation, gross necropsy
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- m-cresol
- EC Number:
- 203-577-9
- EC Name:
- m-cresol
- Cas Number:
- 108-39-4
- Molecular formula:
- C7H8O
- IUPAC Name:
- 3-methyl-phenol
- Details on test material:
- IUCLID4 Test substance: other TS: m-cresol, M.p.: 11-12 C; B.P.: 202.8 C
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 212 g
ENVIRONMENTAL CONDITIONS
- Temperature (°C): room temperature
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: air
- Details on inhalation exposure:
- CONDITIONS:
Room temperature
Total air flow: 10.0 lpm - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- ca. 1 h
- Concentrations:
- 0.71 mg/l
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations daily
- weighing: at the end of the study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology - Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 0.71 mg/L air
- Exp. duration:
- 1 h
- Mortality:
- 0/6
- Clinical signs:
- other: none mentioned
- Body weight:
- mean weight: initial: 212 g; at termination of the study: 256 g
- Gross pathology:
- no significant findings
- Other findings:
- none
Any other information on results incl. tables
RS-Freetext:
Mortality. 0/6; signs of intoxication: none; gross autopsy:
no significant findings
Applicant's summary and conclusion
- Executive summary:
No mortality occurred following the exposure of 6 rats to 0.71 mg/l for 1 hr.and within the 14 day observation period. Clinical signs or findings following sacrifice were not reported.
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