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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Low  toxicity.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
2 064 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
3 000 mg/m³ air

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
3 640 mg/kg bw

Additional information

Neodecanoic acid has a low potential for toxicity via the oral, inhalation, and dermal routes. 



Male and female rats were gavaged with neodecanoic acid at concentrations of 1, 1.5, 2, 3, or 4 ml/kg to assess acute oral toxicity.  All animals that died during the study did so within 3 days of exposure. Signs of toxicity included lethargy, hypothermia, piloerection, dyspnea, and ataxia. Based on these results, it is concluded that the LD50 is approximately 2.27 ml/kg (2066 mg/kg). 



In a study that assessed acute dermal toxicity, male and female rats were exposed to 4 ml/kg (3640 mg/kg) neodecanoic acid via an occluded dermal patch for 24 hours. After 24 hours, the patch was removed and clinical observations were made once daily for 9 days. There were no deaths observed in this study and there were no signs of a toxicity response.  It is concluded that the LD50 is greater than 3640 mg/kg. 



In acute inhalation study, male Wistar rats and Swiss albino mice (10/sex/species) were exposed the test substance vapor via a whole-body exposure at 3.0 mg/L for 6 hours with a subsequent 14 day observation period. No mortality or significant signs of toxicity were observed during the 6-hour exposure period. No deaths occurred in mice or rats throughout the study and no significant observations were made at necropsy. The LC50 is therefore greater than 3 mg/l (3000 mg/m3). 

Justification for classification or non-classification

No classification for acute toxicity (dermal or inhalation) is indicated according to the general classification and labeling requirements for dangerous substances and preparations (Directive 67-548-EEC) or the classification, labeling and packaging (CLP) regulation (EC) No 1272/2008.