Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 273-708-2 | CAS number: 69011-71-8 A scum formed on the surface of molten aluminum and molten aluminum alloys.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Three groups, each of 5 female mice were treated with 25μl of the test item suspended in acetone/olive oil carrier (3:1) at concentrations 25, 12.5 and 6.25% w/v. A fourth group received only the carrier. The item was applied topically on the entire dorsal surface of each ear on Day 1, 2 and 3. On Day 6 mice were dosed with 20μCi3H-methyl thymidine and 5 h later they were sacrificed. The thymidine incorporation in the excised and pooled (per group) lymph nodes was measured. The mean stimulation index (SI) (pooled radioactive incorporation in group/pooled radioactive incorporation control) of each group was calculated. A historical positive group (phenylenediamine) was included. Details of housing and feeding conditions are given. Body weights were recorded individually and were within normal fluctuations. All the animals survived throughout the test without clinical signs. None of the three concentrations reached an SI >3, consequently aluminium dross is not expected to have sensitizing effects.
Migrated from Short description of key information:
The stimulation index of aluminium dross from a local lymph node assay to female mice at concentrations of 25, 12.5 and 6.25% w/v aluminium dross in acetone/olive oil was in every case below 3. As a result the substance is not expected to exhibit sensitizing properties
Justification for classification or non-classification
According to OECD 429 and the criteria given in Annex I of Regulation (EC) 1272/2008, the test item ALUFLUX or Aluminium dross or gray Aluminium dross, as described in this report is expected to have no sensitising properties and therefore, should not be regarded as a dermal sensitiser.
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