Registration Dossier
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EC number: 203-468-6 | CAS number: 107-15-3 EDA
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 952
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 14 day mortality of rats exposed to metered concentrations of EDA vapor for 8h.
- GLP compliance:
- no
Test material
- Reference substance name:
- Ethylenediamine
- EC Number:
- 203-468-6
- EC Name:
- Ethylenediamine
- Cas Number:
- 107-15-3
- Molecular formula:
- C2H8N2
- IUPAC Name:
- ethane-1,2-diamine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 8 h
- Concentrations:
- 2000 ppm corresponding to 4.9 mg/l and 4000 ppm corresponding to 9.8 mg/l
- No. of animals per sex per dose:
- 6 animals per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- 4.9 mg/L air
- Exp. duration:
- 8 h
- Sex:
- male
- Dose descriptor:
- LC100
- Effect level:
- 9.8 mg/L air
- Exp. duration:
- 8 h
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 7.35 mg/L air
- Exp. duration:
- 8 h
- Remarks on result:
- other: Geometric mean of LC0 and LC100
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 14.7 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: Back calculated from 8h exposure using Habers law
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Acute inhalation LC50 was 14.7 mg/l.
- Executive summary:
Rats were exposed to metered concentrations of EDA vapor for 8h. Six male rats per dose group were exposed to 2000 and 4000 ppm EDA vapour for 8h. Mortality of rats was observed for a 14 day period. No deaths were observed in the 2000 ppm dose group, and 100% mortality was observed in the 4000 ppm dose group. Taking the geometric mean as the LC50 value, and calculating back to 4h exposure gives an LC50 of 14.7 mg/l
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