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EC number: 203-468-6 | CAS number: 107-15-3 EDA
Skin and eye irritation tests with rabbit shows that ethylene diamine is corrosive to skin and eye, there is no study available for determiantion of respiratory irritation.
Mean erythema score after 24, 48 and 72 h (animal1/2)
Already a 1 min exposure with ethylenediamine caused necrosis to the exposed skin.
The original BASF grading was converted into the numerical grading according the OECD Draize system.
In a skin irritation/corrosion test, Vienna White rabbits were exposed to ethylene diamine.Two animals were treated for 1, 5 and 15 min using occlusive conditions. An application site of 2.5x2.5 cm was covered with the liquid test substance. After the application time the skin was washed with Lutrol (conc.) and Lutrol/water (1:1). The animals were observed for 14 days and skin changes were recorded daily.
-/-: The original readings at 48 h are missing.
#/# : A thick purlulence layer made an evaluation impossible.
1 h post application heavy opacity and distinct irritation of the mucous membrane were observed and bloody eye discharge occured. Grey discoloration of nictitating and mucous membrane. The severe corneal opacity is regarded to be irreversible.
Two Vienna White rabbits were exposed to 50 µl ethylene amine in one eye. Observations were made after 10 min, 1 and 3 h on the day of treatment and up to 8 days afterwards. The eyes were not washed out after 24 hours as specified in OECD Guideline 405. Irreverible damage to eyes was reported.
Based on the available data for skin corrosion, ethylene diamine is shown to be corrosive to skin. A 1min exposure showed necrosis at observation after 24h.
Irreversible damage to eye after exposure was shown in a study. Observations were made after 10 min, 1 and 3 h on the day of treatment and up to 8 days afterwards. The eyes were not washed out after 24 hours as specified in OECD Guideline 405.
Ethylene diamine is classified as corrosive cat 1B to skin and corrosive to eye according to harmonised EU classification, and the available data supports this classification.
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