Registration Dossier
Registration Dossier
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EC number: 200-817-4 | CAS number: 74-87-3
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Chloromethane is gaseous and the primary environmental compartment to which it partition is air. The substance is not harmful to fish.
Key value for chemical safety assessment
Additional information
Chloromethane is a gaseous substance and primary environmental compartment to which it partition is air. Therefore, thesubstance will evaporate from the water body. As such significant toxicological effects on aquatic organisms are not expected.Available test results from 96-hour toxicity studies indicate chloromethane is of low toxicity toLepomis macrochirus(LC50 = 550 mg/L (Dawson, 1977) and LC50 = 900 mg/L (Hamlin, 1971)), Micropterus salmoides (TL50 = 1500 mg/L (Hamlin, 1971)), and Menidia beryllina (LC50 = 270 mg/L, (Dawson, 1977)). But all test results should be evaluated with caution because optimum test conditions (i. e., measured concentrations, closed system, flow-through conditions) were not met and the reported results may underestimate the toxicity of the test substance. Nonetheless, reported results are comparable to the 96-h LC50 of 396 mg/L predicted by ECOSAR.The ECOSAR model is a reliable and valid QSAR model to apply to chloromethane because it is based on a related chemical dataset. All data show toxicities of chloromethane far in excess of natural occurring concentrations. For these reasons and for the reason of animal welfare no further testing is needed. The substance is not harmful to fish.
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