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EC number: 200-817-4 | CAS number: 74-87-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Endpoint summary
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
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- Long-term toxicity to aquatic invertebrates
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- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 - 26 Nov 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- 1981
- Deviations:
- yes
- Remarks:
- animal weight range exceeds guideline recommendation
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- Deviations:
- yes
- Remarks:
- animal weight range exceeds guideline recommendation
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- The department of health of the government of the United Kingdom
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Chloromethane
- EC Number:
- 200-817-4
- EC Name:
- Chloromethane
- Cas Number:
- 74-87-3
- Molecular formula:
- CH3Cl
- IUPAC Name:
- chloromethane
- Details on test material:
- - Name of test material (as cited in study report): methyl chloride
- Physical state: gaseous
- Analytical purity: 99.9981%
- Purity test date: 2008-10-07
- Lot/batch No.: R7030
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: HsdRccHan (TM):WIST
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Laboratries Ltd., Oxon, UK
- Age at study initiation: 8-12 weeks
- Weight at study initiation: 200-350 g
- Housing: randomly allocated to cages and ear tagged, 5 per sex in solid floor polypropylene cages furnished with soft wood flakes
- Diet: ad libitum Harlan 2014 Rodent Diet, Harlan Laboratories Ltd, Oxon, UK
- Water: ad libitum mains drinking water
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-25
- Humidity (%): 30-70
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- nose only
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: the test material was ducted directly from the gas canister into a 25 L SKC Tedlar Gas Bag (SKC Ltd Dorset, UK). The gas was then transferred from the gas bag to the exposure chamber by means of a Watson Marlow 505S peristaltic pump.
- Exposure chamber volume: 30 L
- Method of holding animals in test chamber: each rat was individually held in a tapered, polycarbonate restraining tube fitted onto a single tier of the exposure chamber and sealed by means of a rubber 'O' ring. Only the nose of each animal was exposed to the test atmosphere.
- Source and rate of air: compressed air
- Method of conditioning air: supplied by means of an oil free compressor and passed through a water trap and respiratory quality filters before it was introduced to the exposure chamber.
- Treatment of exhaust air: exhaust air passed through a scrubber tarp and was connected with a high efficiency filter to a metered exhaust system.
- Temperature, humidity, pressure in air chamber: 19-21 °C, 52-63%, negative air pressure
TEST ATMOSPHERE
- Brief description of analytical method used: samples were removed using a gas-tight syringe and were transferred to 20 mL head space vials for GC-FID analysis
- Samples taken from breathing zone: yes - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- GC-FID
- Duration of exposure:
- 4 h
- Concentrations:
- 4020 mg/m³, 8420 mg/m³ and 21800 mg/m³
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: once per hour during exposure, at the end of exposure, 1 h post-exposure from then on once daily for up to 14 d
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, mortality - Statistics:
- Using the mortality data obtained, an estimate of the acute inhalation median lethal concentration (LC50) of the test material was made.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 21 800 mg/m³ air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- no mortality occured
- Clinical signs:
- other: 4.02 mg/L: Increased respiratory rate was noted in all animals during exposure, on removal from chamber and one hour post-exposure. The animals appeared normal thereafter. 8.42 mg/L: Increased respiratory rate was noted in all animals during exposure, on
- Body weight:
- 4.02 mg/L: no effect on body weight gain compared to controls
8.42 mg/L: 2 females and one male exhibited slight body weight losses or a reduced body weight gain during week 1
21.80 mg/L: 2 females exhibited slight body weight losses or a reduced body weight gain during week 1 and one of them also in week 2
Normal body weight development was noted for all other animals during the course of the study. - Gross pathology:
- Following macroscopic abnormalities were detected amongst several animals at necropsy:
lungs: dark patches
kidneys: speckled appearance
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- DSD: not classified
CLP: not classified
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