Registration Dossier

Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

NOEC (reproduction) = 0.136 mg/L (Daphnia magna, OECD 211, semi-static)
Data from the structurally related ethyl acrylate:
NOEC (reproduction) = 0.19 mg/L (Daphnia magna, EPA OTS 797.1330, flow-through)

Key value for chemical safety assessment

Additional information

A 21 -day Daphnia magna Reproduction Test sponsored by The Acrylate REACh Task Force was performed with Butyl acrylate under semi-static conditions in accordance with OECD TG 211 and GLP regulations (BASF SE, 2009). Nominal test concentrations were 0, 0.1, 0.22, 0.46, 1.0, and 2.2 mg/L. Since the mean values of Butyl Acrylate in M4-medium were found to be in the range of 9.3 – 80.0 % of the nominal concentrations, the effect concentrations were based on the time-weighted mean analytically detected concentrations. The most sensitive effect values were concerning reproduction: NOEC (reproduction) = 0.136 mg/L; LOEC (reproduction) = 0.457 mg/L. Survival of the parent or young daphnia was not effected, but the growth of the parent animals: NOEC (body length) = 0.457 mg/L; LOEC (body length) = 1.226 mg/L.

In addition, for the structurally related ethyl acrylate a 21-day chronic toxicity study performed by ABC Laboratories is available (BAMM, 1997). This study in Daphnia magna was conducted under flow-through conditions according to EPA OTS 797.1330 (BAMM, 1997). Nominal exposure concentrations ranged from 0.38 to 6.0 mg/L. Mean measured test concentrations ranged from 0.19 to 3.2 mg/L. Effect concentrations based on measured values were as follows: EC50 was 0.5 mg/L; NOEC (reproduction) = 0.19 mg/L; LOEC (reproduction) = 0.45 mg/L and MATC (reproduction) = 0.29 mg/L.