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EC number: 205-480-7 | CAS number: 141-32-2
Butyl acrylate is of low toxicity after a single ingestion and short term skin contact. Butyl acrylate is of moderate toxicity after short-term inhalation. Oral: LD50 = 3150 mg/kg bw (rat, BASF Test) Dermal: LD50: 2000 - 3024 mg/kg bw (rabbit, occlusive) Inhalation: LC50 = 10.3 mg/L (rat, OECD TG 403)
Dose (mg/kg bw)
No. of animals
Original value reported: LD50 = 3.5 ml/kg bw (corresponding to ca. 3150 mg/kg bw)
1 . LC50 (4 h) for male and females rats = 11.9 mg/ l air (2275 ppm)
2 . LC50 (1 h) for male and females rats = 47.6 mg / l air (9090 ppm)*
3 . LC50 (4 h) for male rats = 11.2 mg / l air (2140 ppm)
4 . LC50 (1 h) for male rats = 45.0 mg / l air (8555 ppm)*
5 . LC50 (4 h) for female rats = 12.6 mg / l air (2405 ppm)
6 . LC50 (1 h) for female rats = 50.0 mg / l air (9625 ppm)*
* calculated from 4h LC50 values
Oral exposure route:
In an acute toxicity study conducted by BASF AG (1958) groups of 5 - 10 rats were administered doses of 1840, 2840 and 4510 mg/kg bw by gavage and observed for 7 days for lethality and clinical signs of intoxication. The mortality rate was 1/5, 2/5 and 8/10 in the low, mid and high dose groups, respectively. The LD50 was found to be approx. 3150 mg/kg bw. Clinical symptoms were unspecific: staggering gait, piloerection, diarrhea, and in the high dose group only labored breathing, and abdominal position. At necropsy, hyperemia of the medulla renalis was found in the mid and high dose group animals. In another oral gavage study with male rats, a LD50 of 9050 mg/kg bw was determined (Union Carbide, 1971).
Other acute oral LD50 values in rats, rabbits and mice were described mostly without additional data and ranged between 1800 and 8145 mg/kg bw (Union Carbide 1950, Carpenter 1974, Vernot 1977, BASF AG 1958, Tanii 1982). In addition, four other studies were available, but for three of them reliability was unknown (klimisch 4) and one was considered to be unreliable (klimisch 3).
Inhalation exposure route:
In an acute inhalation study conducted according to a protocol similar to OECD TG 403 groups of 10 Sprague-Dawley rats per sex were exposed by head-nose exposure to vapour concentrations of 2.7, 3.6, 4.96, 6.8, 8.1, 12.1 and 16 mg/L (analyzed) for 4 hours and observed for 14 days (BASF AG 1980). The mortality rate was 0/20, 0/20, 0/20, 1/20, 4/20, 13/20 and 20/20, respectively. Clinical signs of toxicity ranged from no symptoms in the lowest dose group; spasmodically breathing, prone position, irregular gait, eye and nasal discharge and piloerection in the middle dose groups; to dyspnoea, trembling and closed eyelids in the high dose group. At necropsy, acute dilatation and hyperemia of the heart, spotted haemorrhages and acute emphysema in lungs and broaden grey-brown periphery of hepatic lobules were observed in the deceased animals. The 4- hour rat LC50 was 10.3 mg/L.
There are several acute vapour inhalation toxicity studies available involving Sprague-Dawley rats, NMRI mice, and Chinese hamsters conducted by BASF AG (1979) according to an internal method equivalent to OECD guideline 403. The studies were performed with fasted and non-fasted animals, but tests with fasted animals are not taken into consideration for the hazard assessment, since fasting represents a physiological stress situation and is not in accordance with the guideline. Nonetheless, the effect values from the six studies were all in the same range, between 6.4 (hamster, non-fasted) and 13.3 (rat, fasted) mg/L. Other acute inhalation toxicity tests in rats mostly without additional data were performed and reported similar or higher values than reported by the key study. In addition, five other studies were available, but for all of them reliability was unknown (klimisch 4).
Dermal exposure route:
The undiluted substance was applied for 24 hours to the intact skin of rabbits under occlusive conditions. The dermal rabbit LD50 values ranged from 2000 mg/kg to 3024 mg/kg (3.36 mL/kg) body weight (Union Carbide 1950, Union Carbide 1971). Erythema and necrosis of the skin were apparent. Iritis occurred in the eyes of the exposed rabbits during the 24 hour exposure period with butyl acrylate. At necropsy, livers were found to be mottled and grayish, with prominent acini; kidneys, spleens and intestines as well as their mesenteries were congested in victims. Occasionally bloody urine was found in the deceased animals.
Sokal et al. (1980) reported LDLo values for rat and rabbit of 1700 mg/kg bw, and Vernot et al. (1977) found a dermal LD50 in rabbits of 5660 mg/kg bw. BASF AG (1958) reported a value of >180 mg/kg bw, which was the only dose tested. In addition, two other studies were available, for one of them the reliability was unknown (klimisch 4) and the other was considered to be unreliable (klimisch 3).
Taking all the presented data into consideration, Butyl acrylate was concluded to be of low toxicity after a single ingestion and short-term skin contact. Butyl acrylate is of moderate toxicity after short-term inhalation.
CLP classification (Regulation (EC) No 1272/2008):
- Inhalation route (vapour): Acute Category 4
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