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Long-term toxicity to fish

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Description of key information

NOEC (91d) = 0.006 mg/L (measured) for Oncorhynchus mykiss (ASTM E 1241-05, read across)

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
0.006 mg/L

Additional information

Since no study assessing the long-term toxicity of Benzaldehyde, 2-hydroxy-5 -dodecyl, oxime, branched (CAS 1233873-37-4) to fish is available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to Phenol, 4-nonyl-,branched (CAS 84852-15-3) was conducted, which is structurally similar to the main component of the substance. The structural difference between the source substance and the target substance is the lack of a aldoxime group at the phenol ring of the molecule and a C9 branched carbon chain instead of a C12 branched carbon chain. The read across is justified by similarity of structure and functional groups and accordingly similar physico-chemical properties, which is expected to result in similar environmental behavior and fate (see table).


Benzaldehyde, 2-hydroxy-5 -dodecyl, oxime, branched

Phenol, 4-nonyl, branched*

CAS number




see attachment (chapter 6.1)

 see attachment (chapter 6.1)

Molecular formula



Molecular weight

~305.46 g/mole

~ 220.35 g/mole

PC parameter



Water solubility

0.3 mg/L (OECD 105)

5.7 mg/L (ASTM E 1148-02)

Partition coefficient

> 5.7 (EU method L3B3 A/63 -73)

5.4 (OECD 117)

Vapour pressure

< 0.39 Pa at 20 °C (estimation based on grain-Watson method)

~1 Pa at 20 °C (ASTM-D 2879)

Environmental fate





non-adapted inoculum:

0 % in 28 days (OECD 301B)


adapted inoculum:

48.2-62 % in 28 days (OECD 301B)

Adsorption [log KOC]

4.4 (OECD 121)

4.35 - 5.69 (EPA OTS 796.2750)


not relevant




Short-term toxicity to fish



0.05 – 0.22 mg/L (different methods)

Long-term toxicity to aquatic invertebrates



0.006 mg/L (ASTM E 1241-05)

Short-term toxicity to aquatic invertebrates



0.08 – 0.14 mg/L (different methods)

Long-term toxicity to aquatic invertebrates



0.024 - 0.116 mg/L (different methods)

Short-term toxicity to algae


498.32 mg/L (OECD 201)

0.33 - 1.3 mg/L (different methods)

Long-term toxicity to algae


101.2 mg/L (OECD 201)

0.5 mg/L (Algal growth inhibition test according to UBA 1984)

Toxicity to microorganisms



950 mg/L (OECD 209)

* Data were taken from Phenol, 4-nonyl-,branched (CAS 84852-15-3) dossier published on the ECHA data base

The available study investigated the long-term toxicity of 4-nonylphenol to early life stage of rainbow trout (Oncorhynchus mykiss) under flow through conditions (Spehar et al. 2010). The study was performed according to ASTM guideline E 1241-05 over an exposure time of 91 days. 100 fertilized eggs per test concentration were exposed to measured concentrations of 6.0, 10.3, 23.1, 53.0 and 114 µg/L 4-nonylphenol. The test system was maintained at ~ 11 ºC and a pH of 6.97. Mean percent hatch of any test concentration was not significantly different from controls. Time to hatch was 39 ± 5 days with swim-up at approximately at day 45. The most sensitive end point was growth. The 91-day NOEC value, based on sublethal effects (growth measured by mean standard length, wet weight and dry weight) is determined to be 6.0 µg/L.

Based on the reasons given above this value is considered to be sufficiently conservative to be used for PNEC derivation of Benzaldehyde, 2-hydroxy-5 -dodecyl, oxime, branched (CAS 1233873-37-4).