Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 264-513-3 | CAS number: 63843-89-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Immunotoxicity
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Immunotoxicological parameters were investigated in a 14 -day study in mice (Ciba-Geigy 1987). Toxicological variables evaluated included: (1) body and selected organ wieights; (2) selected hematological parameters; (3) selected serum chemistry levels; (4) the ability to produce antibody to the T-dependent antigen, sheep erythrocytes; (5) the ability to produce a delayed hypersensitivity response to keyhole limpet hemocyanin; (6) the ability of spleen cells to respond to T-cell mitogens and to allogeneic cells; and (7) the ability of spleen cells to respond to a B-cell mitogen (LPS).
The highest tested dose of 70 mg/kg bw did not cause effects on body weight upon 14 -day dermal exposure. The authors of the study indicate that significant oral exposure may have occurred due to preening as the treated site could easily be reached and no special precautions were taken. The vehicle used was acetone/olive oil and it is one that is typically used in the local lymph node assay.Very little difference was noted between abraded and intact abdominal skin.
The substance in acetone/olive oil, administered daily for 14 days to the abraded or non-abraded skin of B6C3F1 female mice produced changes in the lymphoreticular system, as manifested in a decrease in thymus weight, an increase in spleen weight, an increase in the number of polymorphonuclear leukocytes, an increase in humoral- and cell-mediated immune responses, and a decrease in lymphocyte proliferative responses at 70 mg/kg bw. These changes are consistent with an adjuvant effect. There was also a decrease in erythroid elements in one of the studies.
At the next lower dose of 7 mg/kg bw the only parameter that was changed was the responsiveness of spleen cells to LPS stimulation. The lower response to LPS-induced B-cell proliferation in cultivated spleen cells is difficult to interpret. From the subacute oral data, the substance attracts macrophages in the tissue and in serum causes an increase in monocytes and a relative decrease in lymphocytes. plasma. The lower responsiveness to LPS may simply represent the relative decrease in lymphocytes as a lower number of naive B-cells would be present in the tested cell population.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
