Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-396-5 | CAS number: 106-42-3
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The effects of p-xylene to the early-life stage of fish (Danio rerio/ zebrafish) were determined according to OECD Guideline 210. An extended limit test was conducted under flow-through conditions with the nominal test item concentrations of 2.50 - 5.00 - 10.0 mg/L, corresponding to arithmetic mean measured test item concentrations of 0.714 – 1.29 – 2.79 mg/L. The NOEC and LOEC were determined to be 0.714 and 1.29 mg/L, respectively, based on post-hatch and overall survival.
The estimated NOELR values from TLM QSAR were 0.894 -1.134 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.714 mg/L
Additional information
Noack (2017) measured the effects of p-xylene to the early-life stage of fish (Danio rerio/ zebrafish). The effects were determined according to OECD Guideline 210. An extended limit test was conducted under flow-through conditions with the nominal test item concentrations of 2.50 - 5.00 - 10.0 mg/L, corresponding to arithmetic mean measured test item concentration of 0.714 – 1.29 – 2.79 mg/L. The NOEC and LOEC were determined to be 0.714 and 1.29 mg/L respectively based on post-hatch and overall survival.
Walsh et al (1977) exposed adult fish to mixed xylenes for 56 days in a flow through system. Test concentrations were confirmed by analytical monitoring throughout the exposure period. Measured exposure concentrations were 0.36, 0.74 and 1.3 mg/L. No exposure linked mortality or changes in behaviour were observed at any of the test concentrations (NOEC >1.3mg/L). This study predates the implementation of GLP and study guidelines and deviates significantly from standard chronic fish toxicity tests. In particular, the use of adult fish in the chronic test and the choice of endpoints may result in a less sensitive result than if an embryo-larval or juvenile fish test had been conducted. However, it is well described and is acceptable for use bearing these restrictions in mind.
A TLM-EqP modeling framework was used to support values derived experimentally and are presented as supporting studies.
The estimated NOELR values from TLM QSAR were 0.894 - 1.134 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
