Sodium 3-nitrobenzenesulphonate

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Endpoint:

toxicity to microorganisms

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data is from peer reviewed journal

Justification for type of information:

Data is from peer reviewed journal

Qualifier:

according to guideline

Guideline:

other: As mention below

Principles of method if other than guideline:

Short term toxicity of chemical was studied on the growth of bacteria.

GLP compliance:

not specified

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

other: bacterial sp

Test type:

not specified

Water media type:

not specified

Total exposure duration:

17 h

Reference substance (positive control):

not specified

Key result

Duration:

17 h

Dose descriptor:

EC50

Effect conc.:

> 10 000 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Remarks on result:

other: Other details not known

Validity criteria fulfilled:

not specified

Conclusions:

The effect concentration (EC50) value of test chemical on microorganism (Bacteria sp.) in a 17 hrs study was observed at a dose concentration of > 10000 mg/L.

Executive summary:

Short term toxicity of chemical was studied on the growth of bacteria. The effect concentration (EC50) value of test chemical on microorganism (Bacteria sp.) in a 17 hrs study was observed at a dose concentration of > 10000 mg/L.

Description of key information

Short term toxicity of chemical was studied on the growth of bacteria. The effect concentration (EC50) value of test chemical on microorganism (Bacteria sp.) in a 17 hrs study was observed at a dose concentration of > 10000 mg/L.

Key value for chemical safety assessment

EC50 for microorganisms:

10 000 mg/L

Additional information

Based on the various experimental data for the test chemical and for structurally and functionally similar read across chemicals study have been reviewed to determine the toxic nature of test chemical on the growth of microorganisms. The studies are as mentioned below:

 

In the first key study for the test chemical used from peer reviewed journal toxicity were measured. Short term toxicity of chemical was studied on the growth of bacteria. The effect concentration (EC50) value of test chemical on microorganism (Bacteria sp.) in a 17 hrs study was observed at a dose concentration of > 10000 mg/L.

 

First experimental study was supported by the second supporting study from peer reviewed journal Study was carried out to evaluate the nature of chemical on the bacterial growth. Study was conducted for 17 hrs in which unadapted biological waste water treatment plants were exposed with chemical. Based on the 17 hrs exposure study of bacteria with the test chemical, the EC50 was determine to be 7000 mg/l on the basis of growth rate inhibition.

 

Aim of this third supporting study was to determine the nature of test chemical on the growth of bacteria. Study was conducted for 17 hrs in which unadapted biological waste water treatment plants were exposed with chemical. Based on the growth rate inhibition of bacteria by the test chemical for 17 hrs, the EC50 was 3800 mg/l. Thus the chemical was not highly toxic to the growth of bacteria.

 

Thus based on the above studies, chemical consider to be nontoxic.