Registration Dossier
Registration Dossier
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EC number: 203-571-6 | CAS number: 108-31-6
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- other: data from handbook or collectiion of data
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- other: according to OECD 105
- Water solubility:
- 402 g/L
- Temp.:
- 20 °C
- pH:
- 4
- Key result
- Water solubility:
- 407 g/L
- Temp.:
- 20 °C
- pH:
- 7
- Water solubility:
- 418 g/L
- Temp.:
- 20 °C
- pH:
- 9
- Details on results:
- Stable: no. Hydrolysis to maleic acid occurs in aqueous conditions, so test substance was likely a mixture of maleic anhydride, maleic acid and its salts.
- Conclusions:
- Based on the results presented in the OECD SIDS, 2004, it can be concluded that the water solubility of the test substance is 407 g/L at 20 °C.
- Executive summary:
In a GLP guideline study according to OECD 105, the water solubility of maleic anhydride was investigated. As maleic acid hydrolyses rapidly in water, the concentration of maleic anhydride has been determined via its hydrolisation product – maleic acid. The water solubility of maleic anhydride (as maleic acid) was determined to be 407 g/L at 20 °C.
Maleic anhydride can therefore be considered as a highly soluble substance in water.
Reference
Maleic acid was the analyte measured. Measured concentrations are the result of the mathematical conversion of the actual unrounded concentration of maleic acid to maleic anhydride equivalents. At test termination, pH measurements for all test solutions were <1, indicating that the buffer capacity of the test solution had been exceeded.
Description of key information
In a GLP guideline study according to OECD 105, the water solubility of maleic anhydride was investigated. As maleic acid rapidly hydrolyses in water, the concentration of maleic anhydride was determined via its hydrolysis product – maleic acid. The water solubility of maleic anhydride (as maleic acid) was determined to be 407 g/L at 20 °C.
Maleic anhydride can therefore be considered as a highly soluble substance in water.
Key value for chemical safety assessment
- Water solubility:
- 407 g/L
- at the temperature of:
- 20 °C
Additional information
The substance is hydrolytically unstable at pH 4, 7 and 9 (half-life less than 12 hours). Therefore a.m. value refers to maleic acid.
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