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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: only short documentation

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1966
Report date:
1966

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Method: no data
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methacrylamide
EC Number:
201-202-3
EC Name:
Methacrylamide
Cas Number:
79-39-0
Molecular formula:
C4H7NO
IUPAC Name:
methacrylamide
Test material form:
solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Duration of exposure:
4 hrs
Doses:
20% or 10% solutions
No. of animals per sex per dose:
10
Control animals:
yes
Details on study design:
In this study, 20% or 10% solution of methacrylamide was applied for 4 hours to abdominal skin.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD0
Remarks:
4 hours application
Effect level:
> 1 600 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Executive summary:

In an acute dermal toxicity study 10 rats per dose group were dermally exposed to 20- and 10-% solutions of Methacrylamide in 60% ethanol, (96 %, denatured with 2 % Benzene) 20 % Propanol and 20 % water for 4 hours to 10 % of body surface area. No mortality occured. Only temporary apathie just like the control group with the vehicle was observed.

Dermal LD0 > 1600 mg/kg

Methacrylamide is of low toxicity