Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

direct observations: clinical cases, poisoning incidents and other
Type of information:
other: clinical case report
Adequacy of study:
other information
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference Type:
Dermites de contact dans l'imprimerie, par procédé offset
Ducombs, MM. G. et al.
Bibliographic source:
Soc. Francaise de dermatol. et de syphiligraphie, reunion de Nantes, seance du 27 avril 1974, 408-409

Materials and methods

Study type:
clinical case study
Endpoint addressed:
acute toxicity: dermal
skin sensitisation
Test guideline
no guideline available
Principles of method if other than guideline:
Unspecified epicutaneous tests and biopsies with workers showing contact dermatitis.

Test material

Constituent 1
Chemical structure
Reference substance name:
Acrylic acid
EC Number:
EC Name:
Acrylic acid
Cas Number:
Molecular formula:
prop-2-enoic acid


Type of population:
- Number of subjects exposed: 13
- Sex: male
- Age: 20-52 years
- Known diseases: dermatitis
Ethical approval:
other: ethical appoval given for epicutaneous tests, but only in one case for biopsies
Route of exposure:
Reason of exposure:
unintentional, occupational

Results and discussion

Any other information on results incl. tables

The coworkers only showed effects when exposed to 4 printing inks. To determine the cause of dermatitis (sensitizing or corrosive potential of the inks) it was necessary to take biopsies, but the persons already tested did not want to participate at this procedure. There was only one other volunteer, who was examined by taking a biopsy. According to the authors it could be shown that the effects on the skin were the result of polymerisation of acrylic resins, a reaction where about 16% acrylic acid were released.

Applicant's summary and conclusion