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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficent for assessment

Data source

Reference
Reference Type:
publication
Title:
Dermites de contact dans l'imprimerie, par procédé offset
Author:
Ducombs, MM. G. et al.
Year:
1974
Bibliographic source:
Soc. Francaise de dermatol. et de syphiligraphie, reunion de Nantes, seance du 27 avril 1974, 408-409

Materials and methods

Type of sensitisation studied:
skin
Study type:
case report
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Unspecified epicutaneous tests and biopsies with workers showing contact dermatitis.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Type of population:
occupational
Ethical approval:
other: ethical appoval given for epicutaneous tests, but only in one case for biopsies
Subjects:
- Number of subjects exposed: 13
- Sex: male
- Age: 20-52 years
- Known diseases: dermatitis
Route of administration:
dermal

Results and discussion

Any other information on results incl. tables

The coworkers only showed effects when exposed to 4 printing inks. To determine the cause of dermatitis (sensitizing or corrosive potential of the inks) it was necessary to take biopsies, but the persons already tested did not want to participate at this procedure.

There was only one other volunteer, who was examined by taking a biopsy.

According to the authors it could be shown that the effects on the skin were the result of polymerisation of acrylic resins, a reaction where about 16% acrylic acid were released.

Applicant's summary and conclusion