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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1958
Report Date:
1958

Materials and methods

Principles of method if other than guideline:
BASF-Test
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
- Name of test material (as cited in study report): Acrylic acid, raw, stabilised with approx. 0.2% phenothiazon.
- Analytical purity: 86%
- Composition of test material, percentage of components: Acrylic acid 86%, 2-propenoic acid, 2-carboxylethyl ester, 11%, water 2%,
phenothiazon 0.2%, unknown components 0.8%.

Test animals / tissue source

Species:
rabbit
Strain:
Vienna White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
other: The adjacent eye was treated with one drop of physiological solution of sodium chloride and served as a control.
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied: approx. 50 µl


Duration of treatment / exposure:
21 days
Observation period (in vivo):
21 days
Number of animals or in vitro replicates:
2
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no

SCORING SYSTEM: The original BASF grading was converted into the numerical grading according to the OECD Draize system.

Results and discussion

In vivo

Results
Irritation parameter:
other: Observation of eyes revealed inmmediate corrosion after treatment
Time point:
other: immediately after treatment
Score:
> 4
Reversibility:
not reversible
Other effects:
One drop of indiluted Acrylic acid caused a severe corrosion of the conjunctiva and cornea as a result of an exposure period of 10 minutes. In the course of 8 to 14 days, a complete destruction of the eye was observed and the animal was sacrificed.

Any other information on results incl. tables

One drop of indiluted Acrylic acid caused a severe corrosion of the conjunctiva and cornea as a result of an exposure period of 10 minutes. In the course of 8 to 14 days, a complete destruction of the eye was observed and the animal was sacrificed.

Applicant's summary and conclusion

Interpretation of results:
Category 1 (irreversible effects on the eye) based on GHS criteria