Registration Dossier
Registration Dossier
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EC number: 215-181-3 | CAS number: 1310-58-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Short description of key information:
The in vitro genetic toxicity tests indicated no evidence of mutagenic activity. In addition, both the in vitro and the in vivo genetic toxicity tests with the structurally related sodium hydroxide indicated no evidence of mutagenic activity. According to the REACH Regulation, further in vivo mutagenicity studies shall only be considered in case of a positive result in genotoxic (in vitro) studies (column 2, Annexes VII, VIII). Therefore, further in vivo testing for mutagenicity is not relevant for potassium hydroxide.
Moreover, it is technically not feasible to perform genotoxicity tests at physiological pH with KOH.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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