Registration Dossier

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

Endpoint:
basic toxicokinetics in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2015

Materials and methods

Objective of study:
metabolism
Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: Liquid
Radiolabelling:
no

Results and discussion

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
As the amount of the acrylate (2-Propenoic acid, C12-14-alkyl esters) decreases, the amount of acrylic acid increases in correlation.

Any other information on results incl. tables

Incubation in rat liver S9 mix

The hydrolysis of 2 -Propenoic acid, C12 -14 -alkyl esters shows that the hydrolysis rate of 2 -Propenoic acid, C12 -alkyl ester is in parallel with but a little bit faster than that of 2 -Propenoic acid, C14 -alkyl ester. The amount of acrylic acid increased in correlation with the decrease of 2 -Propenoic acid, C12 -14 -alkyl esters.

Incubation in rat plasma

After 120 minutes a reduction of 2 -Propenoic acid, C12 -14 -alkyl esters of almost 100 % is observed. At the same time the acrylic acid increased by 50 %.

Applicant's summary and conclusion