Registration Dossier

Diss Factsheets

Toxicological information

Additional toxicological data

Currently viewing:

Administrative data

Endpoint:
additional toxicological information
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented publication

Data source

Reference
Reference Type:
publication
Title:
Enhancement of the Excretion of Radiocaesium in Rats by Ferric cyanoferrrate
Author:
Nigrovic, V
Year:
1963
Bibliographic source:
Int. J. Rad. Biol.7,3,307-309

Materials and methods

Principles of method if other than guideline:
Carrier-free 137CsCl and Ferric cyanoferrate (II) (Fe4[Fe(CN)6]3) were administered separately by a gastric tube to rats, who fasted for 20 hours, and the retention of 137Cs assayed by whole- body counting.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Ferric cyanoferrate
IUPAC Name:
Ferric cyanoferrate
Details on test material:
- Name of test material: Ferric cyanoferrate (II)
- Molecular formula: (Fe4[Fe(CN)6]3)

Results and discussion

Any other information on results incl. tables

The results show a pronounced suppression of the enteral 137Cs- absorption even if ferric cyanoferrate (II) was given as late as 60 min after 137Cs -administration.

Since no toxic side- effects were observed even for the highest dosage of Ferric cyanoferrate (II) used, this findings suggest the therapeutic applicability of this agent in cases of accidental incorporation of radiocaesium.

Table 1. 137Cs- retention by rats (96 hours after its oral application) as influenced by oral administration of ferric cyanoferrate (II). Five animals per groups.

 

Ferric cyanoferrate (II)

Body weight (grams)

Percentage of 137Cs- dose (95 per cent fiducial limits)

Percentage of control

Dosage (mg/ animal)

Time of administration (minutes after 137Cs)

0

-

219

58.1 (63.3-53.4)

100

1

2

215

9.42 (13.2-6.72)

16

10

‘’

203

1.17 (1.64-0.84)

2

50

‘’

186

0.57 (0.80-0.41)

1

100

‘’

188

0.52 (0.73-0.37)

0.9

0

-

185

52.5 (51.1-51.0)

100

100

30

184

29.2 (36.8-23.0)

56

100

60

238

31.8 (40.2-25.2)

61

Applicant's summary and conclusion

Categories Display