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Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
Not applicable, calculated value
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance.
Justification for type of information:
The aquatic toxicity was estimated by a QSAR, the Petrotox computer model. This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.
Qualifier:
no guideline followed
Principles of method if other than guideline:
The aquatic toxicity was estimated by a QSAR, the Petrotox computer model. This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.
GLP compliance:
no
Remarks:
The data were calculated by a computer model
Analytical monitoring:
not required
Vehicle:
no
Test organisms (species):
Daphnia magna
Test type:
other: QSAR modeled data
Water media type:
freshwater
Limit test:
no
Total exposure duration:
21 d
Key result
Duration:
21 d
Dose descriptor:
NOELR
Effect conc.:
0.317 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
reproduction
Validity criteria fulfilled:
yes
Conclusions:
The hydrocarbons, C9-C10, n-alkanes, isoalkanes, cyclics, <2% aromatics, estimated freshwater invertebrate 21-day NOELR (No Observed Effect Loading Rate) value is 0.317 mg/l based on reproduction.
Executive summary:

The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism. The hydrocarbons, C9-C10, n-alkanes, isoalkanes, cyclics, <2% aromatics, estimated freshwater invertebrate 21-day NOELR (No Observed Effect Loading Rate) value is 0.317 mg/l based on reproduction.

Description of key information

The hydrocarbons, C9-C10, n-alkanes, isoalkanes, cyclics, <2% aromatics, estimated freshwater invertebrate 21-day NOELR (No Observed Effect Loading Rate) value is 0.317 mg/l based on reproduction.

Key value for chemical safety assessment

Additional information

The hydrocarbons, C9-C10, n-alkanes, isoalkanes, cyclics, <2% aromatics, estimated freshwater invertebrate 21-day NOELR (No Observed Effect Loading Rate) value is 0.317 mg/l based on reproduction.