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Physical & Chemical properties

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1993
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: vaild method (restrictions for low solubility substances)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1993
Report date:
1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: EEC Directive 84/449 (1984) - Methode A7
Deviations:
no
GLP compliance:
yes

Test material

Results and discussion

Solubility in organic solvents / fat solubility
Medium:
other: copra oil (batch n° 41HO182, Sigma)
Solubility:
0 other: g/100 g fat
Temp.:
37 °C
Test substance stable:
not determined

Applicant's summary and conclusion

Conclusions:
Solubility in fat was very low whatever parameter (temperature or stirring time) was modified and no significant differences were observed between the results. Under the experimental conditions described, the fat solubility was estimated to be 1.92 x 10-4 g/100 g fat at 37°C.