Registration Dossier
Registration Dossier
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EC number: 412-550-2 | CAS number: 85776-14-3 GRAPHTOL ORANGE 3RT; PERMANENT ORANGE 2 RLD; PERMANENT ORANGE 3 RTN
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: valid method (restrictions for low solubility substances)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
Constituent 1
Study design
- Analytical method:
- photometric method
Results and discussion
Partition coefficient
- Type:
- Pow
- Partition coefficient:
- > 0.2
- Temp.:
- 21 °C
- Remarks on result:
- other: exact value could not be determined (see below)
- Details on results:
- The test was carried out with presaturation with water and n-octanol. As the solubility in water was under the detection limit (< 0,1 mg/l) the determination of an exact value of the partition coefficient was not possible. The solubility of the test article in n-octanol was determined to be 0.16 mg/L.
Applicant's summary and conclusion
- Conclusions:
- The test was carried out with presaturation with water and n-octanol. As the solubility in water was under the detection limit (< 0,1 mg/l) the determination of an exact value of the partition coefficient was not possible. The solubility of the test article in n-octanol was determined to be 0.16 mg/L. Accordingly log Pow > 0.2
- Executive summary:
The test was performed in tubes. at 21 'C. They were shaked by 120 rotations over five minutes. with a rotary shaker. They were then centrifuged at room temperature. The two phases. in each tube were sampled with a syringe and analysed by UV spectrophotometry..
Taking into account the result of the water solubility « 0.1 mg/I), only the determination of the solubility ot the test article in n-octanol was pertormed.
The test was carried out with presaturation of water and n -octanol. As no test article was detected in the aqueous phase the determination of an exact value of the partition coefficient was not possible.
The solubility of the test article in n-octanol was determined to be 0.16mg/1. Accordingly log Pow > 0.2
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