Registration Dossier
Registration Dossier
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EC number: 204-661-8 | CAS number: 123-91-1
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
The adsorption of the substance to solid soil phase is not expected at environmentally relevant conditions.
Key value for chemical safety assessment
Additional information
QSAR-disclaimer
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of 1,4-dioxane (CAS 123-91-1) (Q)SAR results were used for the estimation of the adsorption potential. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, further experimental studies on the adsorption potential are not provided.
Assessment
According to Regulation (EC) No 1907/2006, Annex VIII, Section 9.3.1, Column 2, the study on adsorption/desorption screening does not need to be conducted if based on the physicochemical properties the substance can be expected to have a low potential for adsorption (e.g. the substance has a low octanol water partition coefficient), or the substance and its relevant degradation products decompose rapidly. The substance has a low partition coefficient (-0.42, Perminova I.V., 1988, see IUCLID Ch. 4.7). In addition, the substance is poorly biodegradable (BASF SE, rep. no.: 27G0155/06G011, 2010). Therefore, a study does not need to be conducted.
To assess the adsorption potential of 1,4-dioxane (CAS 123-91-1) no experimental data exist. Therefore, the Koc value was estimated using QSAR models. According to the MCI method of the KOCWIN v2.00 module of EPI Suite v4.11,
The MCI module estimate for the substance the Koc value of 2.6 L/kg and a log Koc of 0.42 (BASF SE, 2020). The MCI module is more reliable than the log Kow method of KOCWIN v2.00, which estimates the Koc based on the n-octanol/water partition coefficient (log Kow of -0.42 (see IUCLID Ch. 4.7). The latter method resulted in a Koc of 3.25 L/kg and a log Koc of 0.51. The substance was within the applicability domain of the models.
Since 1.4-dioxane is uncharged at physiologically relevant pH values, the estimates are representative for the uncharged molecules of the major components.
It can be concluded, that adsorption to solid soil phase is not expected at environmentally relevant conditions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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