Registration Dossier
Registration Dossier
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EC number: 230-072-0 | CAS number: 6938-94-9
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The PBT Assessment for Diisopropyl adipate (CAS 6938-94-9) is based on the criteria set out in the “Guidance on information requirements and chemical safety assessment, Chapter R.11: PBT Assessment” (ECHA, 2012).
Persistence
Diisopropyl adipate (CAS 6938-94-9) is considered to be readily biodegradable. This assumption is based on a read across to the structurally related substance Dibutyl adipate (CAS 105-99-7). Dibutyl adipate (CAS 105-99-7) was determined as readily biodegradable in a study conducted according to OECD 301C (90% (O2 consumption) after 14 d). Thus, the test substance does not meet the screening criterion for persistence and it is not considered to be P or vP.
Bioaccumulation
The bioaccumulation potential of Diisopropyl adipate (CAS 6938-94-9) is expected to be low. The substance is rapidly metabolised and excreted by organisms and thus an accumulation is not expected. This is supported by calculated low BCF/BAF values (BCF/BAF: 6.299 L/kg; Arnot-Gobas estimate, upper trophic). Thus the substance is not considered to be B or vB.
Toxicity
Diisopropyl adipate (CAS 6938-94-9) is considered to be not toxic. Studies on the acute aquatic toxicity of the substance determined effects > 1 mg/L. A chronic exposure of aquatic organisms is considered unlikely as a consequence of the ready biodegradability. Thus bioaccumulation and chronic toxicity of the substance are not expected. Furthermore the substance is not classified for specific target organ toxicity, carcinogenicity, mutagenicity or reproductive and developmental toxicity in mammals (See Section 5.9). The criteria for “T” based on mammalian effects are therefore not met. Thus, the criteria set out in Annex XIII of Regulation (EC) No. 1907/2006 are not met and the substance is considered to be not T.
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