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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

LC50 (96h) = 3.64 mg/L (measured) for Pimephales promelas (OECD 203, read across to Dibutyl adipate CAS 105-99-7)

Key value for chemical safety assessment

Additional information

One study investigating the short-term toxicity of Diisopropyl adipate (CAS 6938-94-9) to freshwater fish is available. The non-GLP study was conducted under static conditions according to OECD guideline 203 using Danio rerio as test organism (Bouillon, 2012). Four concentrations were tested (control, 13, 32, 50 and 85 mg/L). No analytical dose verification was performed. The 96 h-LC50 was determined to be 37.4 mg/L based on the nominal test concentration.Due to the lack of analytical monitoring and insufficient documentation of test performance, this test was considered to be invalid for assessing the toxicity of Diisopropyl adipate (CAS 6938-94-9) to freshwater fish.Therefore, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances and read-across, a read-across to the structurally related category member Dibutyl adipate (CAS 105-99-7) was conducted.

Further justification is given within the endpoint summary 6.1 and within the category justification section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance within this category was used.

Two studies investigating the short-term toxicity to freshwater fish of Dibutyl adipate (CAS 105-99-7) are available. One semi-static key study was conducted by a Japanese authority according to OECD guideline 203 using Oryzias latipes as test organism (MOE, 1993). Test concentrations between 1 and 10 mg/L were applied. The test concentrations were prepared using a very high vehicle concentration (200 mg/L); however, this is not considered to influence the outcome of the study as (i) the vehicle did not indicate any adverse effects on the test organisms and (ii) the test substance has a water solubility higher than the tested concentrations (water solubility: 35 mg/L). The 96 h-LC50 was determined to be 3.7 mg/L based on the nominal test concentration. This result is confirmed by a second key study, which was conducted under flow-through conditions according to OECD guideline 203 using Pimephales promelas as test organism (Geiger et al., 1985). The applied test concentrations were measured to be between 0.91 and 9.09 mg/L using GLC analysis. The 96 h-LC50 was determined to be 3.64 mg/L based on the measured concentrations.

Due to the structural and property similarities with the tested category member Dibutyl adipate (CAS 105-99-7), this result is also applicable to read across to Diisopropyl adipate (CAS 6938-94-9).