Registration Dossier
Registration Dossier
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EC number: 231-595-7 | CAS number: 7647-01-0
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Chloride ion and hydrogen ion, which combines with water to form the hydronium ion, are both normally present in the body and are also ubiquitous found in the environment. The absorption, distribution, metabolism and excretion of acids and chloride are well known from human and mammalian physiology. Both ions are regulated within a narrow range to maintain homeostasis.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
Hydrogen chloride and its aqueous solution hydrochloric acid are corrosive and irritating and cause direct local effects on the skin, eye and gastro-intestinal or respiratory tract after direct exposure to sufficiently high concentrations. The chemistry of this substance is well understood; as an inorganic salt it dissolves in water to form hydrogen and chloride ions, both of which are physiological electrolytes.
The absorption, distribution, metabolism and excretion of acids and chloride are well known from human and mammalian physiology. Both ions are regulated within a narrow range to maintain homeostasis.
Complete absorption by oral route can be expected. Dermal absorption of dissolved salts on the other hand is generally limited. Related to extreme water solubility and logP value below 0, the ions are too hydrophilic to cross the lipid rich environment of the stratum corneum. Dermal uptake for such solutions of salts in water will be low.
Concentrated hydrogen chloride is corrosive to skin. At concentrations lower than those that cause corrosion, hydrogen chloride will have no systemic toxicity. Dermal exposures should be controlled on the basis of the potential risk to local effects (irritation, corrosion) to the skin. Concentrations that are lower than those that are irritant will only add to the body’s pool of electrolytes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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