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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1938
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Significant methodological deficiencies, information in published paper is insufficient

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1938

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
yes
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Test material form:
other: liquid
Details on test material:
- Physical state: Liquid
- Analytical purity: Commercial grade with 3% isopropyl alcohol

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
not specified

Administration / exposure

Type of coverage:
open
Vehicle:
unchanged (no vehicle)
Duration of exposure:
The material was continuously dripped onto the shaved skin to keep it wet for one hour, while continuously evaporating.
Doses:
Approximately 150 ml of material was used over the course of the hour.
No. of animals per sex per dose:
1 animal
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Remarks on result:
other: LD50 reported by HPV (2008), no LD50 reported by study authors

Any other information on results incl. tables

The procedure resulted in no general ill effect.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: other: CLP (EC 1272/2008)
Conclusions:
The procedure resulted in no general ill effect upon dermal exposure. LD50 of > 2000 mg/kg body weight reported by HPV (2008), no LD50 reported by study authors.