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Long-term toxicity to aquatic invertebrates

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Description of key information

No effects up to the limit of water solubility (WS < 0.05 mg/L)

Key value for chemical safety assessment

Additional information

No experimental data evaluating the chronic toxicity of docosanoic acid, ester with 1,2,3-propanetriol (CAS No. 77538-19-3) to aquatic invertebrates are available. Therefore, toxicity data from a structurally related category member (Glycerides, C14-18 and C16-18 unsatd. mono-, di- and tri-, CAS No. 91052-28-7) are used as read-across in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Both are UVCB substances, formed from the esterification of fatty acids and glycerol, containing long-chain fatty acids (C14-18 and C16-18 unsaturated for CAS No. 91052-28-7 and C16 to C22 for CAS No. 77538-19-3). Furthermore, their water solubilities are comparable (< 0.05 mg/L for both substances). Therefore, these two substances are expected to show similar behaviour in the water phase and comparable degrees of toxicity to aquatic organisms. In fact, acute fish studies conducted with these substances showed no toxicity up to the limit of the water solubility. Based on this information, reading-across from Glycerides, C14-18 and C16-18 unsatd. mono-, di- and tri- is considered justified.

 

The chronic toxicity of Glycerides,C14-18 and C16-18 unsaturated, mono-, di- and tri- (CAS No. 91052-28-7)to aquatic invertebrates has been evaluated by Salinas (2013). This test was conducted according to OECD 211, under GLP conditions. Daphnia magna was exposed to the substance at a single loading rate of 10 mg/L (limit test) for 21 days within a semi-static water regime. At the end of the exposure period, no effects on survival, reproduction or any other adverse effects were reported. Therefore the NOELR was determined to be ≥ 10 mg/L (nominal, loading rate).

 

Based on the results obtained for the structurally related analogue (in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5), docosanoic acid, ester with 1,2,3-propanetriol (CAS No. 77538-19-3) is not expected to show chronic toxicity to aquatic invertebrates up to the limit of its water solubility (< 0.05 mg/L).

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