2-(2-ethoxyethoxy)ethanol

Endpoint summary

Additional information

There is comprehensive data on the toxicity of 2 -(2 -ethoxethoxy)ethanol to fish covering multiple species and both fresh and salt water. The most reliable study is one that used a flow through methodology to examine the 96h acute toxicity in 6 freshwater species. In all but one of these, the LC50 was found to be in the approximate range 10000 to 20,000mg/l. The one exception was Chanel Catfish where the LC50 was established as 6010mg/l. All other 96 hour studies were carried out using static testing. All established LC50's greater than 10,000mg/l, including in a single saltwater species.

There is sufficient information available to characterise the toxicity to aquatic invertebrates. Two studies are available that assessed the toxicity to daphnia magna, the preferred species for testing. The lowest value obtained was an EC50 of 1982mg/l and this is used as the key parameter. In another fresh water crustacea (Calico crayfish) using a flow through method, an EC50 of 34700mg/l was established. A salt water species (purple spined sea urchin) was also examined using a flow through method and an EC50 of 7611mg/l obtained. The data clearly indicates that this substance is practically non toxic to invertebrates.

In a set of experiments designed to generate a dataset for the development of a QSAR model, the toxicity of 2 -(2 -ethoxyethoxy)ethanol ether to the algaeP subcapitatawas assessed using a modified guideline protocol modified to increase throughput and to cope with sealed systems to allow testing of volatile substances. The measured EC50 was 14861mg/L.

There is only one study available providing data on the toxicity of this substance to micro-organisms. This indicates no growth inhibition of sewage micro-organisms up to a concentration of 5000mg/l. It can be concluded that the substance is practically non toxic to sewage micro-organisms.