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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information


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Administrative data

Description of key information

The immunotoxicity caused by Dioctyltin is an acute effect

Key value for chemical safety assessment

Effect on immunotoxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
6.3 ng/kg bw/day
Study duration:
Quality of whole database:

Effect on immunotoxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Effect on immunotoxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Additional information

Several demonstrate clearly, the the immunotoxicity of Dioctyltin is a acute effect. The adverese effects related to the immune system takes place hours after administration of the test substance to the animals. A few hours later there is to changes in the thymus, too.

Justification for selection of effect on immunotoxicity via oral route endpoint:
use of an acuty study, to effect, itest type subacute is chosen in due to default selection criteria

Justification for classification or non-classification

In due to mechanism DOT is to classify as STOT Single 2