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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
extension of an guideline study under glp in pharmaceutical institut; Dioctyltin dilaurate and Tin, dioctylbis(2,4-pentanedionato-κO2,κO4)- hydolyses at once in contact with humidity and / or water at once into dioctlytin oxide and lauric acid respepective intto 2,4-Pentadione.. For the resulting tin level in the blood the hydrolysis product Dioctlytin oxide is responsible
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD 402
Deviations:
yes
Remarks:
additional blood sampling and quantification of Sn in plasma
Principles of method if other than guideline:
Method in OECD 402 was follwoed; additinal bloold sampling for qauntification on Tin in plasma at hour 3 and 24 of treatment
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Dioctyltin dilaurate
EC Number:
222-883-3
EC Name:
Dioctyltin dilaurate
Cas Number:
3648-18-8
Molecular formula:
C40-H80-O4-Sn
IUPAC Name:
dioctyltin dilaurate
Test material form:
other: pure, liquid substance
Radiolabelling:
no

Test animals

Species:
rat
Strain:
other: HsdHan:WIST
Sex:
male/female

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 h
Doses:
2000 mg/kg bw
No. of animals per group:
5 male and female
Control animals:
no

Results and discussion

Percutaneous absorption
Dose:
2000 mg/kg bw
Parameter:
percentage
Absorption:
ca. 0 %
Remarks on result:
other: 3 h
Remarks:
LL0Q = 5 ng/ml
Conversion factor human vs. animal skin:
no conversion factor, in due concentration of Sn in plasma of rats < 5 ng/ml (LL0Q)

Applicant's summary and conclusion

Conclusions:
Tin, dioctylbis(2,4-pentanedionato-κO2,κO4)- is not bioavailable via dermal exposure