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Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
extension of an guideline study under glp in pharmaceutical institut; Dioctyltin dilaurate and Tin, dioctylbis(2,4-pentanedionato-κO2,κO4)- hydolyses at once in contact with humidity and / or water at once into dioctlytin oxide and lauric acid respepective intto 2,4-Pentadione.. For the resulting tin level in the blood the hydrolysis product Dioctlytin oxide is responsible
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD 402
Deviations:
yes
Remarks:
additional blood sampling and quantification of Sn in plasma
Principles of method if other than guideline:
Method in OECD 402 was follwoed; additinal bloold sampling for qauntification on Tin in plasma at hour 3 and 24 of treatment
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Dioctyltin dilaurate
EC Number:
222-883-3
EC Name:
Dioctyltin dilaurate
Cas Number:
3648-18-8
Molecular formula:
C40-H80-O4-Sn
IUPAC Name:
dioctyltin dilaurate
Test material form:
other: pure, liquid substance
Radiolabelling:
no

Test animals

Species:
rat
Strain:
other: HsdHan:WIST
Sex:
male/female

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 h
Doses:
2000 mg/kg bw
No. of animals per group:
5 male and female
Control animals:
no

Results and discussion

Percutaneous absorption
Dose:
2000 mg/kg bw
Parameter:
percentage
Absorption:
ca. 0 %
Remarks on result:
other: 3 h
Remarks:
LL0Q = 5 ng/ml
Conversion factor human vs. animal skin:
no conversion factor, in due concentration of Sn in plasma of rats < 5 ng/ml (LL0Q)

Applicant's summary and conclusion

Conclusions:
Tin, dioctylbis(2,4-pentanedionato-κO2,κO4)- is not bioavailable via dermal exposure

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