Registration Dossier
Registration Dossier
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EC number: 212-791-1 | CAS number: 870-08-6
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- extension of an guideline study under glp in pharmaceutical institut; Dioctyltin dilaurate and Tin, dioctylbis(2,4-pentanedionato-κO2,κO4)- hydolyses at once in contact with humidity and / or water at once into dioctlytin oxide and lauric acid respepective intto 2,4-Pentadione.. For the resulting tin level in the blood the hydrolysis product Dioctlytin oxide is responsible
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 402
- Deviations:
- yes
- Remarks:
- additional blood sampling and quantification of Sn in plasma
- Principles of method if other than guideline:
- Method in OECD 402 was follwoed; additinal bloold sampling for qauntification on Tin in plasma at hour 3 and 24 of treatment
- GLP compliance:
- yes
Test material
- Reference substance name:
- Dioctyltin dilaurate
- EC Number:
- 222-883-3
- EC Name:
- Dioctyltin dilaurate
- Cas Number:
- 3648-18-8
- Molecular formula:
- C40-H80-O4-Sn
- IUPAC Name:
- dioctyltin dilaurate
- Test material form:
- other: pure, liquid substance
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- other: HsdHan:WIST
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per group:
- 5 male and female
- Control animals:
- no
Results and discussion
Percutaneous absorption
- Dose:
- 2000 mg/kg bw
- Parameter:
- percentage
- Absorption:
- ca. 0 %
- Remarks on result:
- other: 3 h
- Remarks:
- LL0Q = 5 ng/ml
- Conversion factor human vs. animal skin:
- no conversion factor, in due concentration of Sn in plasma of rats < 5 ng/ml (LL0Q)
Applicant's summary and conclusion
- Conclusions:
- Tin, dioctylbis(2,4-pentanedionato-κO2,κO4)- is not bioavailable via dermal exposure
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