Registration Dossier
Registration Dossier
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EC number: 268-626-9 | CAS number: 68131-73-7
Endpoint summary
Administrative data
Description of key information
No data are available on the acute oral toxicity and only limited data on acute dermal toxicity of PEPA. However, the registered substance is corrosive and is harmonised classified as 'harmul if swallowed and in contact with skin'. Therefore, no further testing is required according to the standard information requirements in Annex VII and VIII of the Reach Regulation.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
Additional information
There are no data available on acute oral toxicity and only limited data on acute dermal toxicity of polyethylenepolyamine (CAS 68131 -73 -7). The registered substance is harmonised classified as corrosive (H314) and as harmul if swallowed (H302) and in contact with skin (H321). Therefore, according to the standard information requirements set out in Annex VII-VIII, 8.1 and 8.2 of Regulation (EC) No 1907/2006 no further information is required.
Dermal toxicity:
A limited acute dermal toxicity test with the test substance in rabbits revealed a LD50 > 2000 mg/kg bw (Dow, 1983, reliability 4). Two female New Zealand White rabbits were treated with 2000 mg/kg bw test substance. None of the rabbits died within 14 days of observation. After treatment, the rabbits appeared listless and had slight tremors. However, both recovered, appeared healthy, and gained weight during the 2-week observation period.
Justification for classification or non-classification
A harmonised classification for acute oral and dermal toxicity for PEPA is available (Cat. 4, H302 and H312) and thus the registered substance is classified accordingly.
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