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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
22 Mar 2010
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Qualifier:
according to guideline
Guideline:
OECD Guideline 123 (Partition Coefficient (1-Octanol / Water), Slow-Stirring Method)
Principles of method if other than guideline:
not reported
GLP compliance:
no
Type of method:
slow-stirring method
Partition coefficient type:
octanol-water
Analytical method:
other: titration (ISO 2271)
Type:
log Pow
Partition coefficient:
0.3
Temp.:
23 °C
pH:
6.1

Eight measurements were performed, the mean value is chosen as final results:

 

Determ.1

Determ.2

Determ.3

Determ.4

Determ.5

Determ.6

Determ.7

Determ.8

T (°C)

23

23

23

23

23

23

23

23

pH

6.0

6.0

6.0

6.1

6.0

6.1

6.1

6.1

log Pow

0.3

0.3

0.2

0.4

0.4

0.5

0.1

0.1

log Pow (mean value): 0.3

Description of key information

The partition coefficient log Pow is 0.3 at 23 °C, pH 6.1 (OECD 123).

Key value for chemical safety assessment

Additional information

The value of partition coefficient is taken from company data.