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Registration Dossier
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EC number: 500-234-8 | CAS number: 68891-38-3 1 - 2.5 moles ethoxylated
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Occlusive dressing.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Alcohols, C12-14, ethoxylated, sulfates, sodium salts
- EC Number:
- 500-234-8
- EC Name:
- Alcohols, C12-14, ethoxylated, sulfates, sodium salts
- Cas Number:
- 68891-38-3
- Molecular formula:
- not applicable, UVCB
- IUPAC Name:
- Alcohols, C12-14(even numbered), ethoxylated < 2.5 EO, sulfates, sodium salts
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- According to Guideline.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 540 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- No mortality occurred.
- Clinical signs:
- other: No systemic effects.
- Gross pathology:
- No effects.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/ EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008
- Conclusions:
- In this acute dermal toxicity study in rats compliant with OECD TG 402 with deviations, the test substance did not induce mortality when animals were exposed to 2000 mg/kg bw test substance (or 540 mg a.i./kg bw) dermally, covered by an occlusive dressing, for 24 h. Therefore, the LD50 of the test substance was set to > 2000 mg/kg bw (or > 540 mg a.i./kg bw) in male and female rats. Due to the experimental set-up, this result can be interpreted as either Acute Toxicity Category 5 (GHS 2017), or unclassified (Regulation (EC) No 1272/2008).
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