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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: well documented and scientifically acceptable

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977
Reference Type:
publication
Title:
Acute toxicologic evaluation of methylmercaptobenzimidazole
Author:
Bomhard E, Loeser E
Year:
1996
Bibliographic source:
J Am Coll Toxicol 15, S65

Materials and methods

Principles of method if other than guideline:
Seven groups of 10 young adult male Wistar rats (160 -180 g) were dosed at 200, 300, 350, 380, 400, 450, or 500 mg/kg bw Vulkanox MB 2 (CAS 53988-10-6) in Lutrol. The animals were observed for mortality, body weights and clinical signs through day 14
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione
EC Number:
258-904-8
EC Name:
1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione
Cas Number:
53988-10-6
Molecular formula:
C8H8N2S
IUPAC Name:
1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione
Details on test material:
Versuchsprodukt KA 9059 = Vulkanox MB-2/MG; no further data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
polyethylene glycol
Doses:
200, 300, 350, 380, 400, 450, or 500 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
no

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
340 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

Corresponding mortality was 0, 20, 70, 70, 80, 80 and 100% respectively. Sedation was the only clinical sign. Deaths occured on days 1 to 4. The acute oral LD50 for male rats is 340 mg/kg bw (95% confidence interval: 300 - 370 mg/kg bw).

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information
Executive summary:

Seven groups of 10 young adult male Wistar rats (160 -180 g) were dosed at 1 200, 300, 350, 380, 400, 450, or 500 mg/kg bw Vulkanox MB 2 (CAS 53988-10-6) in Lutrol. The animals were observed for mortality, body weights and clinical signs through day 14.

Corresponding mortality was 0, 20, 70, 70, 80, 80 and 100% respectively. Sedation was the only clinical sign. Deaths occured on days 1 to 4. The acute oral LD50 for male rats is 340 mg/kg bw (95% confidence interval: 300 - 370 mg/kg bw).