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EC number: 229-177-4 | CAS number: 6422-99-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The short exposure time of 15 minutes is thought not to impair the evaluation of the skin irritation potential significantly. As a 50% aqueous preparation is the limit of solubility, no higher concentrations would have been achieved if neat AH salt had been tested and this deviation from the test guideline is thought not to impair the evaluation of the skin irritation potential significantly.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 956
- Report date:
- 1956
Materials and methods
- Principles of method if other than guideline:
- Before OECD Guideline 404 was established in 1982, skin irritation was tested using an internal method (BASF test). White Vienna rabbits were used. 2 animals were treated for 1, 5 and 15 minutes using occlusive conditions. An application site of 2.5 x 2.5 cm was covered with the liquid test substance on a patch. After the application time of 1, 5, and 15 minutes, respectively, the skin was first washed with undiluted Lutrol 9, then with an aqueous Lutrol solution (50 %). The skin of the animals that had been treated with the test substance for 20 hours, remained unwashed.
- GLP compliance:
- no
- Remarks:
- pre-GLP study
Test material
- Reference substance name:
- Adipic acid, compound with hexane-1,6-diamine (1:1)
- EC Number:
- 222-037-3
- EC Name:
- Adipic acid, compound with hexane-1,6-diamine (1:1)
- Cas Number:
- 3323-53-3
- IUPAC Name:
- hexanedioic acid - hexane-1,6-diamine (1:1)
- Reference substance name:
- Adipic acid, compound with hexane-1,6-diamine
- IUPAC Name:
- Adipic acid, compound with hexane-1,6-diamine
- Details on test material:
- - Name of test material (as cited in study report): AH-Salz trocken (hexamethylenediamine adipate, dry)
No further data.
The justification of the read-accross is fully detailed in the endpoint summary.
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Breeder
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12h/12h
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- other: not treated skin
- Amount / concentration applied:
- TEST MATERIAL
- Concentration (if solution): 50%; saturated solution; pH = 7.5 - Duration of treatment / exposure:
- 1, 5 and 15 minutes
- Observation period:
- no data
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: back, an application site of 2.5 X 2.5 cm was covered with the liquid (37°C; approx. 1 ml)
REMOVAL OF TEST SUBSTANCE
- Washing: yes, the sites were wiped with a mixture of acetic acid and polyethylene glycol (Lutrol) after the end of the exposure period.
SCORING
Descriptive scores of the raw data have been converted to Draize numerical scores.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- n = 2
- Time point:
- other: unspecified
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects
- Remarks on result:
- other: short-time test with 1; 5; 15 min exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- n = 2
- Time point:
- other: unspecified
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects
- Remarks on result:
- other: short-time test with 1; 5; 15 min exposure
- Irritant / corrosive response data:
- None of two animals showed any effects of irritation at any application site.
Any other information on results incl. tables
primary dermal irritation index (PDII), mean of n=2: Score = 0
Limited documentation; no further details.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the test conditions of this study, the test item, is considered as not irritating to the skin.
- Executive summary:
In a skin irritation study (BASF, 1956), application of a saturated aqueous solution of the test substance (concentration ca. 50%) to the back of two rabbits for up to 15 minutes did not produce any signs of irritation. The short exposure time of 15 minutes is thought not to impair the evaluation of the skin irritation potential significantly. As a 50% aqueous preparation is the limit of solubility, no higher concentrations would have been achieved if neat AH salt had been tested and this deviation from the test guideline is thought not to impair the evaluation of the skin irritation potential significantly.
The primary dermal irritation index (PDII), mean of n=2: Score = 0. Based on these results, the test substance is considered as not irritating to the skin.
By analogy, sebacic acid, compound with hexane-1,6 -diamine (1:1) is not classified according to the CLP regulation 1272/2008/EC and the Directive 67/548/EC criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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