Registration Dossier
Registration Dossier
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EC number: 700-400-1 | CAS number: 42831-50-5
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Ames test was realized according to OECD Guideline 471 (Bacterial Reverse Mutation Assay)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 5-methyl-1,2-oxazole-4-carboxylic acid
- EC Number:
- 700-400-1
- Cas Number:
- 42831-50-5
- Molecular formula:
- C5H5NO3
- IUPAC Name:
- 5-methyl-1,2-oxazole-4-carboxylic acid
Constituent 1
Method
- Target gene:
- The test article was tested for a potential to induce gene mutation in bacteria.
Two independant experiments were performed according to the standard plate incorporation method or the pre-incubation method.
Target gene S.Typhimurium: GC
Target gen E. Coli: AT
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Species / strain / cell type:
- E. coli WP2 uvr A
- Metabolic activation:
- with and without
- Metabolic activation system:
- Rat liver S9 metabolic activation
- Test concentrations with justification for top dose:
- The concentration 1.0, 0.5, 0.1, 0.05 and 0.01mg/plate were chosen for the main experiments.
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
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