Registration Dossier
Registration Dossier
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EC number: 306-832-3 | CAS number: 97416-84-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Basic data given. The justification for the Read Across approach has been attached to the Section 13
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Tetrabromobisphenol A and Derivatived (Environmental health criteria ; 172).
- Author:
- G.J. van Esch
- Year:
- 1 995
- Bibliographic source:
- World Health Organization; IPCS
- Reference Type:
- secondary source
- Title:
- PE-68, Bis (2,3-dibromopropyl ether) of tetrabromobisphenol A
- Author:
- Great Lakes ChemicalCorporation
- Year:
- 1 987
- Bibliographic source:
- Unpublished report
Materials and methods
- Principles of method if other than guideline:
- No available information on the method used.
- GLP compliance:
- not specified
- Test type:
- other: No data available
Test material
- Reference substance name:
- Similar Substance 01
- IUPAC Name:
- Similar Substance 01
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- Application to closely clipped intact skin
- Duration of exposure:
- 24 hours
- Control animals:
- not specified
- Details on study design:
- Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 20 000 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other: No information on confidence level
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information According to the CLP Regulation Criteria used for interpretation of results: EU
- Conclusions:
- LD50 > 20000 mg/kg bw
- Executive summary:
Method
The evaluation of acute dermal toxicity reported from Great Lakes Chemical Corporation (1987)[1] in the WHO publication[2] has been considered in order to complete the assessment.
The test has been conducted in mice; the substance has been applied on closely clipped intact skin for 24 hours. The animals have been observed for 14 days after application. No further information on the method used is available.
Results
The dermal LD50 reported in this reviews on the Similar Substance 01 is greater than 20000 mg/kg bw.
[1] Great Lakes Chemical Corporation (1987) Summaries of toxicity data. PE-68, Bis(2,3-dibromopropyl ether) of tetrabromobisphenol A. West Lafayette, Indiana, Great Lakes Chemical Corporation (Unpublished report submitted to WHO by the Brominated Flame Retardant Industry Panel).
[2]World Health Organization (WHO, Geneva, 1995); Dr. G.J. van Esch “Tetrabromobisphenol A and Derivatived” (Environmental health criteria; 172)
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