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Registration Dossier
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EC number: 243-697-9 | CAS number: 20292-08-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 Dec - 23 Dec 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- only basic data given, test substance purity not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-ethylhexyl laurate
- EC Number:
- 243-697-9
- EC Name:
- 2-ethylhexyl laurate
- Cas Number:
- 20292-08-4
- Molecular formula:
- C20H40O2
- IUPAC Name:
- 2-ethylhexyl laurate
- Details on test material:
- - Name of test material (as cited in study report): Laurate d´Ethyle 2 Hexyle
- Analytical purity: no data
- Lot/batch No.: 05022
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not required
- Duration of treatment / exposure:
- single application
- Observation period:
- Reading time points: 1, 24, 48 and 72 h
7 days - Number of animals:
- 3
- Details on study design:
- SCORING SYSTEM: Draize scoring system
Results and discussion
In vitro
Results
- Remarks on result:
- not measured/tested
In vivo
Results
- Remarks on result:
- not measured/tested
Any other information on results incl. tables
Table 1: Results of skin irritation study
Observation time |
Animal no. |
|||||
1 |
2 |
3 |
||||
Erythema |
Edema |
Erythema |
Edema |
Erythema |
Edema |
|
1 h |
0 |
0 |
0 |
0 |
1 |
0 |
24 h |
2 |
0 |
2 |
0 |
2 |
0 |
48 h |
1 |
0 |
2 |
0 |
2 |
0 |
72 h |
0 |
0 |
0 |
0 |
2 |
0 |
7 d |
0 |
0 |
0 |
0 |
0 |
0 |
Mean value 24 + 48 + 72 h |
1.0 |
0 |
1.33 |
0 |
2.0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
DSD: not classified
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