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Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original report not available.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
IUCLID dataset
Author:
IULCID4
Year:
2000
Reference Type:
study report
Title:
Unnamed

Materials and methods

Principles of method if other than guideline:
not given
GLP compliance:
yes
Type of assay:
micronucleus assay

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethylhexyl laurate
EC Number:
243-697-9
EC Name:
2-ethylhexyl laurate
Cas Number:
20292-08-4
Molecular formula:
C20H40O2
IUPAC Name:
2-ethylhexyl laurate
Details on test material:
- Analytical purity: not given

Test animals

Species:
mouse
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Duration of treatment / exposure:
24, 48 and 72 h
Frequency of treatment:
no data
Post exposure period:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
1.25, 2.5, 5.0 mL/kg bw
Basis:
nominal conc.
No. of animals per sex per dose:
no data
Control animals:
not specified

Examinations

Tissues and cell types examined:
no data

Results and discussion

Test results
Sex:
male/female
Genotoxicity:
negative
Toxicity:
not specified
Vehicle controls validity:
not specified
Negative controls validity:
not specified
Positive controls validity:
not specified

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative