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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

not irritant to skin (technical product: 50% MPAAU in water) nor to eye 
Respiratory irritation: waived

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2003-10-22 till 2004-03-27
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study with GLP without deviations.
Justification for type of information:
QSAR not applicable for organic salt compound MPAAU.
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Species:
rabbit
Strain:
New Zealand White
Type of coverage:
occlusive
Preparation of test site:
other: clipping
Vehicle:
water
Controls:
other: The untreated other side served as control.
Amount / concentration applied:
0.5 ml technical product
Duration of treatment / exposure:
4 hours
Observation period:
Animals were examined for signs of erythema and oedema at 1, 24, 48 and 72 hours after patch removal.
Number of animals:
3
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Max. score:
0
Reversibility:
other: no effect
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Max. score:
0
Reversibility:
other: no effect
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Max. score:
0
Reversibility:
other: no effect
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Max. score:
0
Reversibility:
other: no effect
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Max. score:
0
Reversibility:
other: no effect
Irritation parameter:
edema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Max. score:
0
Reversibility:
other: no effect
Irritant / corrosive response data:
none
Other effects:
no effect observed.
Interpretation of results:
GHS criteria not met
Conclusions:
As the mean value for erythema or oedema were "0" for all 3 animals after a test period of 4h and a observation period of 24,48 and 72 h, the test material is be considered as a "non irritant".
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation, other
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 1983-08-18 till 1983-08-29
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study without GLP.
Justification for type of information:
QSAR and in-vitro methods not available at that time.
QSAR not applicable for organic salt compound MPAAU.
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Version / remarks:
May 12, 1981
Deviations:
no
GLP compliance:
no
Species:
rabbit
Strain:
New Zealand White
Vehicle:
unchanged (no vehicle)
Controls:
other: the left eye of the test animals remained untreated
Amount / concentration applied:
0.1 ml of the test item was placed into the conjunctival sac of the right eye of each animal.
Number of animals or in vitro replicates:
3 animals
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 1h, 24h, 48h, 72h, 7 days
Score:
0
Max. score:
0
Reversibility:
other: no effect
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 1h, 24h, 48h, 72h, 7 days
Score:
0
Max. score:
0
Reversibility:
other: no effect
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 1 h
Score:
1
Max. score:
1
Reversibility:
fully reversible within: 24 h
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 1 h
Score:
1
Max. score:
1
Reversibility:
fully reversible within: 24 h
Irritant / corrosive response data:
not irritating
Other effects:
The body weight in 2 animals was decreased during the test period.
Interpretation of results:
GHS criteria not met
Conclusions:
The test item is non irritant and not corrosive when applied to the rabbit eye mucosa.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for selection of skin irritation / corrosion endpoint:
GLP study with Klimisch score 1 available.

Justification for selection of eye irritation endpoint:
GLP study with Klimisch score 1 available.

Justification for classification or non-classification

According to the GHS criteria, listed in Annex I, the substance does not have to be classified as a hazardous substance regarding irritation/corrosion.