Ethyl vinyl ether

Eye irritation

Administrative data

Endpoint:

eye irritation, other

Remarks:

in vivo study already available

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Guideline study with acceptable restrictions (no details about test substance)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1988

Report date:

1988

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 405 (Acute Eye Irritation / Corrosion)

Deviations:

no

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Ethyl vinyl ether

EC Number:

203-718-4

EC Name:

Ethyl vinyl ether

Cas Number:

109-92-2

Molecular formula:

C4H8O

IUPAC Name:

ethoxyethene

Details on test material:

ethyl vinyl ether (EVE), no further data

Test animals / tissue source

Species:

rabbit

Strain:

Vienna White

Details on test animals or tissues and environmental conditions:

TEST ANIMALS
- Source: GAUKLER ; OFFENBACH (FRG)
- Age at study initiation: no data
- mean weight at study initiation: 3.4 (males) and 3.2 kg (female)
- Housing: singly
- certified diet and tap water ad libitum
- Acclimation period: 8 days


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12

Test system

Vehicle:

unchanged (no vehicle)

Amount / concentration applied:

undiluted
Amount applied: 0.1 mL

Duration of treatment / exposure:

no washing

Observation period (in vivo):

Eye reactions were examined after 1, 24, 48, and 72 h after application

Number of animals or in vitro replicates:

3 (two male and one female)

Details on study design:

0.1 ml of undiluted TS was placed into the conjunctival sack of the rabbit's eye. The substance was not washed out. Effects were scored according to the table of Draize contained in the OECD TG 405.

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

conjunctivae score

Basis:

mean

Time point:

other: 1 h

Score:

1.7

Max. score:

3

Reversibility:

fully reversible

Remarks on result:

other: no effects 48 h after application; no effects on iris and cornea at any reading

Results 2

Irritation parameter:

conjunctivae score

Basis:

mean

Time point:

other: 24 h

Score:

1.3

Max. score:

3

Reversibility:

fully reversible

Remarks on result:

other: no effects 48 h after application

Results 3

Irritation parameter:

chemosis score

Basis:

mean

Time point:

other: 1 h

Score:

0.66

Max. score:

4

Reversibility:

fully reversible

Remarks on result:

other: no effects 48 h after application

Results 4

Irritation parameter:

chemosis score

Basis:

mean

Time point:

other: 24 h

Score:

0.3

Max. score:

4

Reversibility:

fully reversible

Remarks on result:

other: no effects 48 h after application

Irritant / corrosive response data:

No corneal opacity was noted in any of the animals at any reading, i.e. the mean score = 0 for all readings in all animals.
Iritis: no effect in any animal at any time, therefore mean score = 0.
Conjunctivae: mild and well-defined reddening, discharge and swelling was noted at 1 hour and to a lesser degree at 24 hrs post treatment. No effect was noted at 48 and 72 hrs post treatment.

Other effects:

no

Applicant's summary and conclusion

Interpretation of results:

slightly irritating

Remarks:

Migrated information

Conclusions:

In three White Vienna rabbits the instillation of 0.1 mL of the undiluted test substance into the conjunctival sac of one eye caused reddening (grade 1 - 2) and slight swelling (grade 1) 1 & 24 hours after application (no washing). The findings cleared up 48 hours after application. No effects were noted on cornea or iris.